The University of Michigan Health System is the medical unit of the University of Michigan in Ann Arbor.

Already one of the largest health care complexes in the world, the university, in 2005, unveiled a development master-plan for the medical campus that is expected to add 3 million square feet to the existing 5 million square feet.

The current complex includes both the U-M Medical School, which opened in 1850, and the first university owned and operated hospital in United States history.

In 2004, total sponsored research expenditures was about $300 million. In 1956, James Neel created the first department of human genetics at a medical school in the United States.

The system has three hospitals, including University Hospital, C.S. Mott Children's Hospital, and Women's Hospital. There are also approximately thirty health centers, 120 outpatient clinics. The system also operates three helicopters and a Cessna jet in a medical evacuation program titled Survival Flight.